10 Dermatologist-Tested Skin Care Products That Are Like Botox in a Bottle

From the age of 10, people lose about one percent of their collagen (the protein that makes up the skin's structure) every year. Therefore, you should start nourishing your dermis early with products and ingredients to keep it looking and feeling strong and healthy. Dermal fillers and injectables, such as Botox, have been shown to have a skin-firming effect, says dermatologist Blair Murphy-Rose, MD. "

Like many trends, the term "Botox in a Bottle" originated on TikTok. "It refers to topical skin care products—and I mean everything from creams to serums—that can reduce and smooth the appearance of fine lines and wrinkles on the face," says dermatologist Deanne Mraz Robinson, MD. These are typically topical products containing neurotransmitter inhibitor peptides or protein fragments that block nerves from sending contraction signals to muscles, adds Dr. Murphy Ross added. “They reduce muscle activity that wrinkles the skin and causes fine lines and wrinkles (just like Botox!).”

1. Ordinary Matrixyl 10% + HA 30ml

If you don’t want to spend a lot of money on a serum, The Ordinary is your best option. "This special formula contains Matrixyl 3000 and hyaluronic acid to plump and hydrate the skin," Dr. Murphy-Ross. "Matrixyl 3000 is a powerful anti-aging ingredient that stimulates the production of collagen and elastin, Effectively combats fine lines and wrinkles and improves skin elasticity, texture and moisture.”

PhD. Murphy-Rose also adds that collagen-stimulating ingredients like Matrixyl 3000 are generally well tolerated and less irritating than retinol, making them suitable for all skin types.

Warm review: "You can't get a better peptide for the price. In fact, I think I saw a slight improvement. I use it during the day and hyaluronic acid at night. I'm 70 years old and my skin looks better than Most 50-year-olds are better." No wrinkles at all.

2. Skinbetter Science InterFuse Intensive Treatment Series

Do you want smooth, firm skin without needles? Look no further than this hyaluronic acid treatment, which claims to improve deep facial expression lines (see you soon, crow's feet).

PhD. Robinson says this treatment is a great alternative to Botox because it doesn't require needles to keep the skin smooth. “I always recommend that my patients use it in conjunction with in-office treatments as it can further improve their results.”

Warm review: "This is a must! I use it on my forehead, around my mouth, and on my frown lines and it helps smooth out fine lines. It feels different than other hyaluronic acid serums and has a bigger effect."
3. Juice Beauty Stem Cell Anti-Wrinkle Moisturizer

The cream, a top-seller in the skin tightening category on Amazon, contains active, antioxidant-rich ingredients like fruit stem cells and vitamin C, as well as jojoba and shea butters. The brand claims that these ingredients are just what you need if your goal is moisturized, hydrated, and firmer skin, even if you're battling deep wrinkles. Apply daily to face, neck and chest for best results over time.

glowing review: "I used this to treat deep wrinkles in my forehead area. After two weeks, everyone at work was asking me if I was going to change my makeup routine because they couldn't see my lines anymore."
4. Peter Thomas Roth Instant FIRMx Temporary Firming Eye Cream

The groundbreaking eye tightener went viral on TikTok in 2021, praised for its "miraculous" ability to get rid of under-eye bags in minutes. There's no doubt why users still crave it so much today. In the formula, you'll find "a concentrated blend of multiple peptides and neuropeptides, including the patented Syn-Ake, Argireline, and Matryxl 3000 that reduce muscle contractions," says Dr. Murphy-Ross. It's perfect for pre-makeup or pre-Zoom Skin preparation.

glowing review: "I don't usually write reviews but had to for this product. I have genetic bags under my eyes - the older I get, the worse they look. This product does a great job of temporarily reducing them Good." It starts working within five minutes and you can feel it getting stronger. I love this product. "

5. Neostrata Triple Firming Neck Cream
Have you noticed wrinkles and signs of aging on your neck? Your first reaction may be to panic, but Neostrata Firming Neck Cream can help. It contains high amounts of neoglucosamine, a non-amino sugar that, according to the brand, soothes discoloration (goodbye, age spots!). Is it in the bottle too? Amino acids said to plump skin.

Warm review: "I've only had this neck cream for a few weeks, but it's very moisturizing and my neck lines have shrunk a bit. I've only used regular moisturizer on my neck for years, but this is definitely better."

6. Chantecaille Bio Firming Mask+
Any Chantecaille mask is going to deliver some serious results, but this one stands out. Enriched with an instant-smoothing seaweed blend and peptide stem cell extract, this mask refines and smoothes wrinkles, making your skin appear firmer. For best results, the brand recommends applying a thin layer to skin for 15 minutes twice a week.

Warm review: "I've only used this mask a few times, but have already received so many compliments on my skin. I leave it on overnight and then wash it off in the morning. It feels light and absorbs quickly." This Works better than any other anti-aging mask I've ever used.

7. ISDIN Melatonin Essence

PhD. Robinson highly recommends this product if you want to restore elasticity and reduce the appearance of fine lines and wrinkles. "It's a nighttime regenerating serum that works while you sleep to help repair the damage caused during the day."
This product contains bakuchiol, a retinol alternative that's great for sensitive skin types. "This serum also contains melatonin and vitamin C to rejuvenate skin and give it a healthy glow," says Robinson.

Warm review: "This product is amazing in the bottle. It's so light that it feels like nothing is on your face. It penetrates your skin on contact and provides ideal moisture levels. "A little goes a long way. "I use it every night and my face is glowing in the morning."
8. U Beauty Rejuvenating Cream

I would describe UBeauty's Skin Resurfacing Complex as: powerful, transformative, and skin-perfecting. It combines exfoliating ingredients with nourishing ingredients to eliminate dullness, even out skin tone, reduce fine lines and refine texture.

It's also natural, pure and vegan, contains no fillers and is safe to use on all skin types if you want your skin to look refreshed quickly.

Warm review: "I love this product - it's lightweight and goes on very smoothly on my face. The product works really well. My skin looked great the next day, with a more even and radiant complexion."
9. Biossance Squalane + Hyaluronic Acid Peptide Plumping Serum

If the name of this product seems a mouthful, that's because the formula contains enough ingredients to make your tongue tie. But they all work synergistically.

Take a look at the ingredients list and you'll find copper peptides to support collagen and elasticity production, a patented rapid plumping complex made with hydrating hyaluronic acid and squalane, and Paragress extract, which the brand says can visibly Tightens the skin.

glowing review: "This product is amazing. I have oily, acne-prone skin and show signs of aging. It absorbs into the skin very well and makes me look radiant without being greasy. I try it I've tried other cheaper copper peptide serums but they gave me rashes and didn't do anything for my skin. This is the only thing I'll use."
10. Sincerely, Wutong dual-purpose line limiter
This tinted serum can be used on the face and lips before makeup to soften expression lines and fill in fine lines. Inside the tube is a potent blend of natural ingredients like Dense Hibiscus and Restorative Fruity Fragrance and synthetic ingredients like sustainably sourced vegan collagen.

To apply the product, use the metal tip of the applicator to massage around lips and other wrinkles and expression lines before applying makeup. For smoother results, use twice daily.

Editor's comment: "I swear it's like Botox overnight. I'm too scared to get real Botox injections, but I have so many wrinkles on my forehead. My friend recommended it to me and I Swear it clears all lines overnight, and the results last for days. I notice a noticeable difference in my skin when I'm not using it." - Neha Tandon, WH Senior Business Editor


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