Is it safe to use niacinamide to treat active acne?


 Yes, niacinamide is safe to use to treat active acne. A 2017 study found that using niacinamide for 6-8 weeks significantly reduced acne. Additionally, research shows that taking supplements containing niacinamide by mouth is effective in reducing acne.

Some teenagers experience temper tantrums that may persist into adulthood. However, adult acne is a serious problem that requires special care. Niacinamide is one of the best active ingredients for treating adult acne. 

Niacinamide is a form of vitamin B3 found in nuts, mushrooms, and fish. It has antibacterial, antimicrobial, anti-inflammatory, pathogenic, antiadhesive, antiproliferative and antibiofilm properties.

Niacinamide treats acne, hyperpigmentation, excess sebum production, signs of aging, photosensitivity, irritation, and dryness. Read on to learn more about the safety of niacinamide for treating active acne. 

 Is it safe to use niacinamide to treat active acne? A 2016 study found that using niacinamide at a concentration of 4% to treat active acne was safe and resulted in acne relief.

Another 2020 study concluded that a gel containing 4% nicotinamide was effective in treating mild to moderate acne and pustules. Its anti-inflammatory effects are equivalent to topical clindamycin for acne treatment. 

The anti-inflammatory properties of niacinamide can treat papular and pustular acne and reduce the redness associated with acne. It also reduces pore size. The anti-inflammatory properties of niacinamide can reduce the number and severity of acne lesions.

It reduces post-inflammatory hyperpigmentation and prevents the formation of pigmented spots. A 2010 study found that topical 2-3% nicotinamide (alone or with N-acetylglucosamine) could control the progression of hyperpigmentation. 

 4. Strengthen skin barrier. The skin barrier is crucial as it protects the skin from environmental threats such as fungi, bacteria, viruses and moisture loss. A damaged or weakened barrier can lead to inflammation and irritation.

Niacinamide is a water-soluble vitamin commonly used to treat skin conditions. Due to its antioxidant effects, it also repairs damaged DNA. Acne vulgaris is associated with impaired skin barrier function, and nicotinamide can penetrate human skin and strengthen the skin barrier. 

Acne: Negative Effects and Responsible Factors. Acne is a chronic inflammatory skin disease characterized by whiteheads, blackheads, nodules, papules, and pustules. Young people face multiple side effects of acne.

This can lead to permanent scarring, skin disfigurement, emotional distress and discomfort. For some people, it can also cause embarrassment and anxiety and reduce social and physical well-being. 



Some factors that contribute to acne include stress, youth, smoking, male gender, genetics, and comedogenic medications (corticosteroids, halogens, androgens, and pore-clogging cosmetics). Previous research has shown that genetically determined sebum overproduction combined with comedostimulating hormones leads to acne lesions.

Niacinamide combination for active acne treatment. Combining niacinamide with other active ingredients can safely control acne more effectively. You can use them individually to avoid the risk of irritation or interaction with topical medications; for example, use niacinamide as part of your morning care routine and use topical benzoyl peroxide or retinoids at night. The following compounds are effective in treating acne: Benzoyl peroxide unclogs pores and eliminates acne-causing bacteria. 

Retinol reduces the appearance of scars, increases collagen production by penetrating deep into the skin, removes oil and dead skin cells, and exfoliates pores. Salicylic acid is a chemical peel that penetrates deeply and cleanses pores.

It is effective in treating non-inflammatory acne. Vitamin C has antioxidant properties that reduce hyperpigmentation, inflammation, acne, and scarring. 

Zinc reduces acne breakouts due to its antibacterial and anti-inflammatory properties and suppresses sebum production due to its anti-androgenic properties. NOTE: If you don’t want to use niacinamide, you can use any of the above ingredients.

How does niacinamide treat acne? 
Niacinamide treats acne in the following ways. 

1. Reduce sebum secretion and fight active acne. Niacinamide has the potential to reduce sebum production. It inhibits the activity of sebocytes (sebum-producing cells), leading to reduced sebum production and oily skin.  

Its anti-inflammatory properties treat papular acne (small, inflamed bumps that form due to excess oil) and pustular acne (small, blister-like, pus-filled inflamed sores). A 2016 study found that using 2% topical niacinamide reduced sebum production rates after two to four weeks of use. 

2. Reduce bacterial growth Niacinamide has anti-mycobacterial properties that may help treat acne vulgaris. It provides long-lasting bacterial protection. One study also showed that niacinamide increases skin antimicrobial activity and has the potential to kill bacteria (Staphylococcus aureus and E. coli) within 6 hours. It also inhibits cell proliferation and growth of Plasmodium falciparum and Mycobacterium tuberculosis. 

3. Anti-inflammatory

Post a Comment